GUIDE ON APOMORPHINE PRESCRIPTION / INFUSION IN PARKINSONS DISEASE PATIENTS
Creutzfeldt-Jakob disease (CJD)
Creutzfeldt-Jakob disease (CJD) Case Report (Published Geriatric Medicine, UK Nov 2018) Authors Rachel Bennett – Advanced Nurse Practitioner, Sherwood Forest Hospitals NHS Foundation Trust Dr Slavka Ulikova – Specialty Doctor in Geriatric, Sherwood Forest Hospitals NHS Foundation Trust Dr Nishantha Silva – Consultant Physician and Geriatrician, Clinical Lead for Parkinson’s Disease, Sherwood Forest Hospitals NHS Foundation Trust; Nishantha.silva@nhs.net Introduction. Creutzfeldt-Jakob disease (CJD) is a human prion disease that exists in four forms; that of sporadic, genetic, iatrogenic and variant (Knight 2006). Human prion diseases share common neuropathological features such as spongiform degeneration, astrocytic gliosis and neuronal loss associated with amyloid plaques (Will & Ironside 2017). The prion protein is a cellular protein that changes through an unknown mechanism from its normal structure (PrPc) to PrPsc which is insoluble, resistant to protease
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